AgingReG
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Aging Overview

External factors

External factors: 4-(4-fluorophenyl)-2-phenyl-5,6,7,8-tetrahydroquinoline
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Ovarian cancer
Experimental category: L
Tissue type: --
Cell name: IMR-90,A2780
PMID: 29143360
Experiment: SA-β-gal activity assay//Western blot
Description: FPTHQ treatment dramatically increased the number of SA - β -gal positive A2780 cells.FPTHQ -treatment increased the protein levels of MMP3 and the mRNA levels of IL-6 and IL-8 in A2780 cells.

Regulatory relationship

Regulatory pathway: p21
R-EF-Pathway: Upregulation
Official symbol(s): CDKN1A
Pathway experiment: SA-β-gal activity assay//Western blot
Pathway description: In addition, we found that p21 was significantly up -regulated after FPTHQ treatment.Consistent with the observations in other two cell lines, FPTHQ also significantly increased the protein level of p21 in SKOV -3 cells.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

AKT phosphorylates targets in the cytosolAngiopoietin receptor Tie2-mediated signalingC-MYB transcription factor networkCi/Gli processing signaling ( Hedgehog signaling pathway ) Class I PI3K signaling events mediated by AktConstitutive Signaling by AKT1 E17K in CancerCyclin A:Cdk2-associated events at S phase entryCyclin D associated events in G1Cyclin E associated events during G1/S transitionDirect p53 effectorsDNA Damage/Telomere Stress Induced SenescenceE2F transcription factor networkFormation of Senescence-Associated Heterochromatin Foci (SAHF)Gli processing signaling ( Hedgehog signaling pathway ) Glucocorticoid receptor regulatory networkInterleukin signaling pathwayNotch signaling pathwayOrc1 removal from chromatinp53-Dependent G1 DNA Damage Responsep53 pathwayp53 pathway feedback loops 2p73 transcription factor networkRegulation of nuclear SMAD2/3 signalingRegulation of retinoblastoma proteinSCF(Skp2)-mediated degradation of p27/p21Senescence-Associated Secretory Phenotype (SASP)Signaling events mediated by HDAC Class IIISignaling events mediated by PRLTGF_beta_ReceptorThe role of GTSE1 in G2/M progression after G2 checkpointTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestValidated targets of C-MYC transcriptional repressionValidated transcriptional targets of TAp63 isoformsVinblastine Action PathwayVincristine Action PathwayVindesine Action PathwayVinorelbine Action PathwayErbB signaling pathwayCell cyclep53 signaling pathwayHepatitis CPathways in cancerGliomaProstate cancerMelanomaBladder cancerChronic myeloid leukemiaHs_Cell_Cycle_WP179_89516Hs_ErbB_Signaling_Pathway_WP673_91869Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974Hs_DNA_Damage_Response_WP707_82937Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193Hs_Integrated_Cancer_Pathway_WP1971_82939Hs_ATM_Signaling_Pathway_WP2516_90247Hs_LncRNA-mediated_mechanisms_of_therapeutic_resistance_WP3672_87395Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520Hs_AMP-activated_Protein_Kinase_(AMPK)_Signaling_WP1403_90259Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687Hs_Retinoblastoma_(RB)_in_Cancer_WP2446_87639Hs_TGF-beta_Signaling_Pathway_WP366_90028Hs_Androgen_receptor_signaling_pathway_WP138_79958
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)