| External factors: | HCV infection |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | HCV infection |
| Experiment: | SA-β-gal activity assay |
| Description: | SA-β-gal expression increased in senescent CD4+ T cells in HCV-infected patients compared with age-matched HS. |
| Regulatory pathway: | DNp63-miR18-1a-SIRT1 |
| R-EF-Pathway: | -- |
| Official symbol(s): | YAP1-SIRT1 |
| Pathway experiment: | Flow cytometry//Western blot//RT-PCR |
| Pathway description: | The protein levels of Sirt1 were significantly upregulated in CD4+T cells from 22 HCV-infected patients compared with 22 age-matched HS；We then silenced the expression of DNp63 in CD4+T cells from patients with HCV and found that lower expression of DNp63 in T cells by transfecting its specific siRNA led to an up-regulation of miR-181a and a down-regulation of Sirt1 expression. |
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