Aging Overview

External factors

External factors: HCV infection
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: HCV infection
Experimental category: L
Tissue type: Blood
Cell name: CD4+T
PMID: 27354409
Experiment: SA-β-gal activity assay
Description: SA-β-gal expression increased in senescent CD4+ T cells in HCV-infected patients compared with age-matched HS.


Regulatory relationship

Regulatory pathway: DNp63-miR18-1a-SIRT1
R-EF-Pathway: --
Official symbol(s): YAP1-SIRT1
Pathway experiment: Flow cytometry//Western blot//RT-PCR
Pathway description: The protein levels of Sirt1 were significantly upregulated in CD4+T cells from 22 HCV-infected patients compared with 22 age-matched HS;We then silenced the expression of DNp63 in CD4+T cells from patients with HCV and found that lower expression of DNp63 in T cells by transfecting its specific siRNA led to an up-regulation of miR-181a and a down-regulation of Sirt1 expression.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.