External factors: | HCV infection |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Other |
Phenotype: | HCV infection |
Experiment: | SA-β-gal activity assay |
Description: | SA-β-gal expression increased in senescent CD4+ T cells in HCV-infected patients compared with age-matched HS. |
Regulatory pathway: | DNp63-miR18-1a-SIRT1 |
R-EF-Pathway: | -- |
Official symbol(s): | YAP1-SIRT1 |
Pathway experiment: | Flow cytometry//Western blot//RT-PCR |
Pathway description: | The protein levels of Sirt1 were significantly upregulated in CD4+T cells from 22 HCV-infected patients compared with 22 age-matched HS;We then silenced the expression of DNp63 in CD4+T cells from patients with HCV and found that lower expression of DNp63 in T cells by transfecting its specific siRNA led to an up-regulation of miR-181a and a down-regulation of Sirt1 expression. |
Annotation: