| External factors: | PTX |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cervical cancer |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | In HeLa and SiHa cells treated with PTX + CIS the percentage of SA-β? Gal(+) was significantly lower (22.9 ± 7.5% and 27.2 ± 5.4 %, respectively) which represents a 3.6 and 3-times lower diminution in relationship to senescence induced by CIS alone ( P < 0.001). In untreated control groups, the apoptotic index was ≤ 13. In contrast, in all treated groups, important levels of apoptosis were detected, because when HeLa and SiHa tumor cells were treated with PTX alone, the apoptotic indexes were 43.8 ± 4.4 and 46.2 ± 2.4 respectively ( P < 0.001 vs untreated group). |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: