Aging Overview

External factors

External factors: Trans-Resveratrol
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Diabetes
Experimental category: L
Tissue type: Aorta
Cell name: --
PMID: 23859249
Experiment: SA-β-gal activity assay
Description: The number of senescence-associated β-galactosidase (SAβgal)-stained cells in a SA-βgal assay increased significantly in the thoracic aortas of STZ-diabetic mice but decreased in the thoracic aortas of the G. gnemon extract-administered mice.


Regulatory relationship

Target gene: SIRT1
R-EF-Target gene: Upregulation
Official symbol(s): SIRT1
Target gene experiment: Immunofluorescence
Target gene description: Immunostaining of sections for SIRT1 showed that SIRT1 expression in aortic endothelial cells increased after administration of the extract to STZ-diabetic mice.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.