| External factors: | Trans-Resveratrol |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Diabetes |
| Experiment: | SA-β-gal activity assay |
| Description: | The number of senescence-associated β-galactosidase (SAβgal)-stained cells in a SA-βgal assay increased significantly in the thoracic aortas of STZ-diabetic mice but decreased in the thoracic aortas of the G. gnemon extract-administered mice. |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | Immunofluorescence |
| Target gene description: | Immunostaining of sections for SIRT1 showed that SIRT1 expression in aortic endothelial cells increased after administration of the extract to STZ-diabetic mice. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: