Aging Overview

External factors

External factors: Lipid lowering therapy
Aging type: Prevent
Aging characteristic:
Category: Other
Phenotype: Coronary artery disease
Experimental category: HL
Tissue type: Blood
Cell name: PBMC
PMID: 28646123
Experiment: FISH
Description: The aggressive LLT group showed reduced LDL cholesterol levels in CAD patients after 12 months of therapy.


Regulatory relationship

Target gene: MIR-23A//TRF2
R-EF-Target gene: Downregulation//Upregulation
Official symbol(s): MIR-23A//TERF2
Target gene experiment: qRT-RCR//Flow cytometry
Target gene description: Aggressive LLT markedly decreased levels of miR-23a (2.78±1.29 vs. 2.09 ±1.17, P < 0.01) and increased levels of TRF2 (2.98 ± 1.44 vs.3.52 ± 1.34, P < 0.01).

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.