| External factors: | Fluidic substrate |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Lung cancer |
| Experiment: | Cell viability assay//Cell cycle analysis |
| Description: | The viability of the cancer cells on non-crosslinked P(CL-co-DLLA) substrates was significantly decreased to 57% and 32% for 48 h and 72 h respectively.Cells on crosslinked P(CL-co-DLLA) substrate showed a reduced G0/G1 phase (13.87%) and increased S phase (75.55%). However, cells on non-crosslinked P(CL-co-DLLA) substrate showed an accumulation of G0/G1 phase (66.3%) and reduction of S phase (13.92%). |
| Target gene: | IGFBP5//P53 |
| R-EF-Target gene: | Upregulation//Upregulation |
| Official symbol(s): | IGFBP5//P53 |
| Target gene experiment: | Immunofluorescence//Confocal microscopy//RT-PCR |
| Target gene description: | At 72 h, cells on the non-crosslinked P(CL-co-DLLA) substrate showed a significant induction of IGFBP5 mRNA .At day 3, p53 bands were significant only for cells grown on the non-crosslinked P(CL-co-DLLA) substrate. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: