| External factors: | Palbociclib |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Hepatocellular carcinoma |
| Experimental category: | L |
| Tissue type: | Patient-derived HCC tissue |
| Cell name: | HuH-7,SK-HEP-1 |
| PMID: | 27849562 |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | Only two of the cell lines, Huh7 and skHep1, were consistently positive for staining. Furthermore, after palbociclib treatment, these two cell lines displayed flat and enlarged morphology, suggesting that they could have undergone senescence.Analysis of tumours collected after treatment with vehicle or palbociclib (for 16?days) showed that palbociclib-treated tumours were positive for the senescence marker SAβGAL . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: