Aging Overview

External factors

External factors: Protease inhibitors
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Lipodystrophic syndromes
Experimental category: L
Tissue type: --
Cell name: Fibroblast
PMID: 17612587
Experiment: SA-β-gal activity assay//BrdU assay
Description: Strong cellular staining for 5-bromo-4-chloro-3-indolyl-β-D-galactoside (X-gal) at pH 4, indicating physiological lysosomal β-galactosidase activity, was detected in control fibroblasts and in those bearing LMNA mutations or treated with PIs.LMNA mutations and PI treatment also induced a striking decrease in fibroblasts’ replicative capacity, measured in terms of bromodeoxyuridine (BrdU) incorporation in halfconfluent cells .


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.