| External factors: | Protease inhibitors |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Lipodystrophic syndromes |
| Experiment: | SA-β-gal activity assay//BrdU assay |
| Description: | Strong cellular staining for 5-bromo-4-chloro-3-indolyl-β-D-galactoside (X-gal) at pH 4, indicating physiological lysosomal β-galactosidase activity, was detected in control fibroblasts and in those bearing LMNA mutations or treated with PIs.LMNA mutations and PI treatment also induced a striking decrease in fibroblasts’ replicative capacity, measured in terms of bromodeoxyuridine (BrdU) incorporation in halfconfluent cells . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: