Aging Overview

External factors

External factors: Paclitaxel
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Gastric cancer
Experimental category: L
Tissue type: --
Cell name: MKN45
PMID: 25483095
Experiment: SA-β-gal activity assay//Flow cytometry
Description: SA-β-galactosidase activity staining showed a clear increase in cellular senescence in these cells after PTX treatment compared with control MKN45 cells. PTX causes a prometaphase arrest cell cycle that, if sustained, generates DNA damage and senescence.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.