| External factors: | H2O2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cervical cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | C3 cells expressing hTERTC27 exhibited a significantly reduced growth rate after the H2O2 challenge compared to the control EGFP expressing A1 cells. Furthermore, at 7 days after H2O2 treatment, the C3 cells became enlarged and flattened, lost cell-to-cell contact, and stained positively forSA β-gal. |
| Target gene: | P21 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | P21 |
| Target gene experiment: | Western blot |
| Target gene description: | Western blot analysis showed that in C3 cells, a sustained increase of p21Waf1 protein level was observed from day 1 to at least day 9. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: