| External factors: | Metformin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Breast cancer |
| Experiment: | Cell morphological analysis |
| Description: | We determined that 1 mM metformin proved to be a threshold concentration at which impaired cell proliferation was evident at 72 hours, Heterochromatic nuclei were observed in metformin treated cells, indicative of senescence in cells previously exposed to 1 mM metformin. Morphologically, cells exposed to metformin are enlarged and flattened, consistent with induction of stress-induced senescence. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: