| External factors: | UVB irradiation |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | The ratio of senescent cells was markedly greater following UVB irradiation (74.4%) compared with cells that had not been exposed to irradiation (15.7%). |
| Target gene: | MALAT1//MMP1 |
| R-EF-Target gene: | Upregulation//Upregulation |
| Official symbol(s): | MALAT1//MMP1 |
| Target gene experiment: | RT-PCR//ELISA |
| Target gene description: | Results further demonstrated that 60 mJ/cm2 UVB increased MALAT1 expression.The results demonstrated that MALAT1 siRNA suppressed MALAT1 expression and inhibited 60 mJ/cm2 UVB-induced MMP-1 secretion . |
| Regulatory pathway: | MAPK |
| R-EF-Pathway: | Activation |
| Official symbol(s): | MAPK |
| Pathway experiment: | Western blot |
| Pathway description: | The results demonstrated that 60 mJ/cm2 UVB upregulated ERK, JNK and p38 phosphorylation levels. |
Annotation: