Aging Overview

External factors

External factors: Cilostazol
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HUVEC
PMID: 19520256
Experiment: SA-β-gal activity assay
Description: Treatment with cilostazol inhibited the senescent phenotype induced by sirolimus or everolimus at 10 days. Under treatment with sirolimus or everolimus (2.5 nmol/l), 49.2% or 53.0% of cells were SA-βgal positive, versus only 13.6% or 14.6% of cilostazol (100 μmol/l)-treated cells under the same conditions.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.