| External factors: | Morin |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experimental category: | L |
| Tissue type: | Foreskin |
| Cell name: | Human interfollicular epidermal stem cell |
| PMID: | 23952478 |
| Experiment: | SA-β-gal activity assay |
| Description: | Morin significantly inhibited UVB-induced accumulation of SA-β -gal in KSC. |
| Target gene: | TNF-α//IL-1 β//IL-6 |
| R-EF-Target gene: | Downregulation//Downregulation//Downregulation |
| Official symbol(s): | TNF//IL1B//IL6 |
| Target gene experiment: | ELISA |
| Target gene description: | However, morin led to a significant decrease in the production of TNF- α , IL-1 β , and IL-6 in the UVB-irradiated KSC. |
| Regulatory pathway: | ATM |
| R-EF-Pathway: | -- |
| Official symbol(s): | ATM |
| Pathway experiment: | Flow cytometry//Western blot |
| Pathway description: | Flow cytometric result showed that fl uorescence intensity of ATM phosphorylation was 74.7% value in the morin-treated KSC compared with 86.1% value in UVB-irradiated KSC. As a result, ATM-related signaling pathway molecules (Chk2, p53, and H2A.X), MAPK family members (JNK/SAPK and p38/MAPK), and S6RP were rapidly phosphorylated in response to UVB irradiation in KSC . |
Annotation: