Aging Overview

External factors

External factors: Resveratrol
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: EPC
PMID: 18587418
Experiment: SA-β-gal activity assay
Description: Resveratrol influenced EPCs senescence dose dependently, with a maximal inhibitory effect achieved at 50mM.


Regulatory relationship

Target gene: TELOMERASE
R-EF-Target gene: Activation
Official symbol(s): TELOMERASE
Target gene experiment: Western blot
Target gene description: Resveratrol dose dependently increased telomerase activity, with a maximal increase at 50mM.

Regulatory pathway: PI3K-Akt
R-EF-Pathway: --
Official symbol(s): PIK3CB-AKT
Pathway experiment: Western blot
Pathway description: Stimulation with resveratrol led to dose-dependent phosphorylation of Akt, although it did not affect the total amount of Akt.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view