Aging Overview

External factors

External factors: Drug abuse
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HFA
PMID: 28612507
Experiment: SA-β-gal activity assay//Cell morphological analysis//Western blot
Description: Meth significantly induced SA-β-Gal expression even at the lower meth dose of 10 lM ;Meth-treated HFAs demonstrated a classical flat morphology of senescent astrocytes ;Meth also increased the expression of another marker of cell senescence, p161NK4A, as evaluated by Meth also increased the expression of another marker of cell senescence, p161NK4A, as evaluated by Western blot.


Regulatory relationship

Regulatory pathway: β-catenin
R-EF-Pathway: Downregulation
Official symbol(s): CTNNBIP1
Pathway experiment: SA-β-gal activity assay
Pathway description: Meth at 300 lM inhibited TOPflash activities by approximately 45%.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.