AgingReG
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Aging Overview

External factors

External factors: Ergothioneine
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Type 2 diabetes mellitus
Experimental category: L
Tissue type: --
Cell name: Endothelial cell
PMID: 27101740
Experiment: Cell morphological analysis
Description: The Egt treatment in the presence of hGluc (EgtthGluc) resulted in a morphological adjustment to the control cell-like small spindle shape.

Regulatory relationship

Regulatory pathway: SIRT1//SIRT6//NF-κB
R-EF-Pathway: Upregulation//Upregulation//Downregulation
Official symbol(s): SIRT1//SIRT6//NFKB1
Pathway experiment: Confocal microscopy//Immunofluorescence//Western blot
Pathway description: Specifically, SIRT1 arbitrary fluorescence units (AFU) were significantly decreased by 48 h treatment with hGluc whereas EgtthGluc cells showed a SIRT1 fluorescence intensity significantly higher than that observed in hGluc cells.These effects were blocked by Egt and, more in details, SIRT6 expression in EgtthGluc cells was 78.373.1 AFU vs 49.273.1 AFU in hGluc cells, whereas NF-κB expression was 48.971.8 AFU vs. 12473.3 AFU in hGluc cells . Moreover, a reduced SIRT6 downregulation and a reduced NF-κB upregulation were observed during hGluc treatment in the presence of Egt (EgtthGluc).

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

AndrogenReceptorCircadian ClockE2F transcription factor networkFoxO family signalingHIF-2-alpha transcription factor networkp53 pathwayp73 transcription factor networkRegulation of Androgen receptor activityRegulation of HSF1-mediated heat shock responseRegulation of retinoblastoma proteinRORA activates gene expressionSignaling events mediated by HDAC Class ISignaling events mediated by HDAC Class IIISIRT1 negatively regulates rRNA ExpressionHs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Simplified_Interaction_Map_Between_LOXL4_and_Oxidative_Stress_Pathway_WP3670_90107Hs_Energy_Metabolism_WP1541_91584Hs_Sterol_Regulatory_Element-Binding_Proteins_(SREBP)_signalling_WP1982_90425Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178Hs_SREBF_and_miR33_in_cholesterol_and_lipid_homeostasis_WP2011_89947
Processing of DNA double-strand break endsSignaling events mediated by HDAC Class IHs_SREBF_and_miR33_in_cholesterol_and_lipid_homeostasis_WP2011_89947
Activation of NF-kappaB in B cellsAlternative NF-kappaB pathwayamb2 Integrin signalingAngiopoietin receptor Tie2-mediated signalingApoptosis signaling pathwayAtypical NF-kappaB pathwayBCRBCR signaling pathwayCanonical NF-kappaB pathwayCD209 (DC-SIGN) signalingCD40/CD40L signalingCeramide signaling pathwayCLEC7A (Dectin-1) signalingCLEC7A/inflammasome pathwayDEx/H-box helicases activate type I IFN and inflammatory cytokines productionDownstream TCR signalingEGFR1EPO signaling pathwayFc-epsilon receptor I signaling in mast cellsFCERI mediated NF-kB activationGlucocorticoid receptor regulatory networkHIV-1 Nef: Negative effector of Fas and TNF-alphaIkBA variant leads to EDA-IDIKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)IKK-NF-kappaB cascade ( B cell receptor signaling ) IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) IKK-NFkB cascade ( TNFR1 signaling pathway ) IL1-mediated signaling eventsIL1IL12-mediated signaling eventsIL2IL2 signaling events mediated by PI3KIL23-mediated signaling eventsIL3IL4IL5IL6Interleukin-1 processingIntracellular Signalling Through Adenosine Receptor A2a and AdenosineIntracellular Signalling Through Adenosine Receptor A2b and AdenosineLeptinLPA receptor mediated eventsMAP3K8 (TPL2)-dependent MAPK1/3 activationNF-kB is activated and signals survivalNF-kB signaling ( Toll-like receptor signaling pathway (trough NF-kappaB) ) NotchOsteopontin-mediated eventsProlactinRANKLRegulated proteolysis of p75NTRRegulation of TelomeraseRIP-mediated NFkB activation via ZBP1Senescence-Associated Secretory Phenotype (SASP)Signaling events mediated by HDAC Class IT cell receptor signaling (PLC gamma, PKC, Ras and IKK-NF-kappaB cascade) ( CD4 T cell receptor signaling (NF-kB cascade) ) T cell receptor signaling pathway ( CD4 T cell receptor signaling ) TAK1 activates NFkB by phosphorylation and activation of IKKs complexTCRTGF_beta_ReceptorTNF receptor signaling pathway TNFalphaTRAF6 mediated NF-kB activationTranscriptional regulation of white adipocyte differentiationTSLPTWEAKMAPK signaling pathwayChemokine signaling pathwayApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathwayT cell receptor signaling pathwayB cell receptor signaling pathwayNeurotrophin signaling pathwayAdipocytokine signaling pathwayEpithelial cell signaling in Helicobacter pylori infectionShigellosisLeishmaniasisChagas diseaseToxoplasmosisAmoebiasisHepatitis CPathways in cancerPancreatic cancerProstate cancerChronic myeloid leukemiaAcute myeloid leukemiaSmall cell lung cancerHs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017Hs_Factors_and_pathways_affecting_insulin-like_growth_factor_(IGF1)-Akt_signaling_WP3850_88165Hs_Leptin_signaling_pathway_WP2034_89856Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910Hs_Apoptosis_Modulation_by_HSP70_WP384_67054Hs_Glucocorticoid_&_Mineralcorticoid_Metabolism_WP237_78497Hs_Allograft_Rejection_WP2328_90020Hs_Oxidative_Damage_WP3941_90810Hs_T-Cell_Receptor_and_Co-stimulatory_Signaling_WP2583_86147Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794Hs_TNF_alpha_Signaling_Pathway_WP231_89895Hs_IL17_signaling_pathway_WP2112_89838Hs_Estrogen_signaling_pathway_WP712_78491Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527Hs_TLR4_Signaling_and_Tolerance_WP3851_90114Hs_IL1_and_megakaryocytes_in_obesity_WP2865_88662Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178Hs_Prolactin_Signaling_Pathway_WP2037_90015Hs_AGE-RAGE_pathway_WP2324_89798Hs_IL-4_Signaling_Pathway_WP395_89828Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937Hs_IL-1_signaling_pathway_WP195_89932Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)