| External factors: | 3×mAbs |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Lung cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | Indeed, treatment of cultured PC9 and H1975 cells with 3×mAbs induced prominent activity of SA‐β‐Gal. |
| Target gene: | DCR2//P16//P21//P27/KIP |
| R-EF-Target gene: | Upregulation//Upregulation//Upregulation//Upregulation |
| Official symbol(s): | TNFRSF10D//P16//P21//P27/KIP |
| Target gene experiment: | Western blot |
| Target gene description: | Elevation of additional senescence markers was noted in vitro, such as DCR2 (TNFRSF10D) and several inhibitors of cyclin‐dependent kinases, namely p16, p21, and p27/KIP. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: