Aging Overview

External factors

External factors: 3×mAbs
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Lung cancer
Experimental category: L
Tissue type: --
Cell name: PC-9,H1975
PMID: 29212784
Experiment: SA-β-gal activity assay
Description: Indeed, treatment of cultured PC9 and H1975 cells with 3×mAbs induced prominent activity of SA‐β‐Gal.


Regulatory relationship

Target gene: DCR2//P16//P21//P27/KIP
R-EF-Target gene: Upregulation//Upregulation//Upregulation//Upregulation
Official symbol(s): TNFRSF10D//P16//P21//P27/KIP
Target gene experiment: Western blot
Target gene description: Elevation of additional senescence markers was noted in vitro, such as DCR2 (TNFRSF10D) and several inhibitors of cyclin‐dependent kinases, namely p16, p21, and p27/KIP.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.