Aging Overview

External factors

External factors: CS extract
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: HL
Tissue type: --
Cell name: HTBE
PMID: 27093475
Experiment: SA-β-gal activity assay//Western blot//Cell Cell proliferation assay
Description: Furthermore,CSE treatment in control cells significantly increased GDF15 protein (up to 43-fold) and SA β-gal activity (up to 43% SA β-gal positive cells), inhibited cell proliferation (up to 54% decrease), and relocated HMGB1 protein from the intracellular milieu into the extracellular milieu.


Regulatory relationship

Target gene: GDF15
R-EF-Target gene: --
Official symbol(s): GDF15
Target gene experiment: SA-β-gal activity assay//Western blot//Cell proliferation assay
Target gene description: Disruption of GDF15 markedly reduced CSEinduced cellular senescence, represented by less induced SA β-gal activity, less inhibition of cell proliferation, and less HMGB1 release.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.