External factors: | CS extract |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Other |
Phenotype: | Aging |
Experiment: | SA-β-gal activity assay//Western blot//Cell Cell proliferation assay |
Description: | Furthermore,CSE treatment in control cells significantly increased GDF15 protein (up to 43-fold) and SA β-gal activity (up to 43% SA β-gal positive cells), inhibited cell proliferation (up to 54% decrease), and relocated HMGB1 protein from the intracellular milieu into the extracellular milieu. |
Target gene: | GDF15 |
R-EF-Target gene: | -- |
Official symbol(s): | GDF15 |
Target gene experiment: | SA-β-gal activity assay//Western blot//Cell proliferation assay |
Target gene description: | Disruption of GDF15 markedly reduced CSEinduced cellular senescence, represented by less induced SA β-gal activity, less inhibition of cell proliferation, and less HMGB1 release. |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: