Aging Overview

External factors

External factors: HDAC inhibitor(sodium butyrate(NaBu) and valproic acid(VPA))
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: Blood,Adipose
Cell name: AD-MSC,UCB-MSC
PMID: 20049504
Experiment: SA-β-gal activity assay
Description: We extended the treatment period up to 7 days, where we observed tha MSCs acquired a senescent phenotype based on SA-β-gal staining.


Regulatory relationship

Target gene: JMJD3//P16//SUZ12//BMI1//EZH2//C-MYC
R-EF-Target gene: Upregulation//Upregulation//Downregulation//Downregulation//Downregulation//Downregulation
Official symbol(s): KDM6B//P16//SUZ12//BMI1//EZH2//C-MYC
Target gene experiment: RT-PCR//Western blot
Target gene description: hUCB- and hADMSCs showed decreased expression of c-MYC, BMI1 and SUZ12. JMJD3 was upregulated by 1-day treatment of HDAC inhibitors, and its expression level peaked at 3 days of treatment. p16INK4Awas slightly increased from 3 days of treatment of HDAC inhibitors.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.