| External factors: | Homocysteine |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | Coculture of HUVECs with homocysteine resulted in an increase in percentage of SA-β-gal-positive cells with a maximum effects achieved at 4 μM . In the prolonged culture, the number of SA-β-gal-positive cells at 4μM progressively rose from ~5% at day 1 to 24% at day 7. Over the 7-day period in culture, homocysteine produced as much as about five-fold increase in the percentage of senescent endothelial cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: