| External factors: | 17β-estradiol |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cardiovascular disease |
| Experiment: | SA-β-gal activity assay |
| Description: | The ratio of arterial senescence area was lower in OVX＋E2 mice than in OVX mice .The premature senescence of HUVEC treated with ox-LDL was inhibited by administration of E2. |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | Immunostaining |
| Target gene description: | Continuous administration of E2 from an E2 pellet increased SIRT1 expression in the endothelial cells of ApoE-KO OVX mice. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: