| External factors: | Doxorubicin |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Cell morphological analysis//SA-β-gal activity assay |
| Description: | Most of them acquired enlarged flat morphology typical for senescence and developed acidic β-galactosidase activity. |
| Regulatory pathway: | p53-p21 |
| R-EF-Pathway: | Activation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | Doxorubicin led to a pronounced accumulation of p21 and p53 in control cells. |
Annotation: