| External factors: | Irradiation |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Prostate cancer |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | In contrast, an equivalent dose of IR (4 Gy) induced SA-β-gal expression in approximately 75% of the LNCaP cells and 50% of the 22Rv1 cells.increased the proportion of senescent cells 5 days after IR. |
| Target gene: | P53 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | P53 |
| Target gene experiment: | Western blot |
| Target gene description: | IR (6 Gy) was sufficient to induce a rapid (<30 min) and sustained (>180 min) phosphorylation of p53 (at Ser15) by kinases such as ATM .In contrast, both the accumulation of p53 protein and transactivation of its downstream target, p21, were consistently delayed and more persistent in 22Rv1 cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: