Aging Overview

External factors

External factors: Propolis extrac
Aging type: Prevent
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HDF
PMID: 28826096
Experiment: SA-β-gal activity assay//Trypan blue staining
Description: Pretreatment the cells with 50 and 100 mg/ml concentrations of EEP decreased the number of positive β-galactosidase cells significantly (P < 0.01);The results of trypan blue exclusion test indicated that propolis at the concentration of 100 mg/ml not only did not reduce the number of viable cells in EEP-treated cells, but also it preserved the viabilityof irradiated HDF cells.


Regulatory relationship

Target gene: FOXO3A//NGF
R-EF-Target gene: Upregulation//Upregulation
Official symbol(s): FOXO3A//NGF
Target gene experiment: qPCR
Target gene description: Data analysis revealed that EEP itself at concentration of 100mg/ml markedly increased the expressions of FOXO3A and NGF genes in HDF cells.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.