| External factors: | UV irradiation |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | qRT-PCR |
| Description: | mRNA expression of type I collagen, the major structural protein in the human skin, was significantly reduced by acute UV irradiation in the dermis.In contrast, mRNA expression of collagen-degrading MMP-1, the primary collagen-degrading enzyme in human skin, was significantly elevated by acute UV irradiation in the dermis.(Aging characteristics：reduced type I collagen production and increased fragmentation of the dermal collagenous extracellular matrix). |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: