| External factors: | Red wine extract |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Comet assay//Western blot |
| Description: | Treatment with RWE concentration dependently decreased endothelial senescence by maximally 33+?7.1 %.RWE clearly reduced tBHP-induced DNA damage and p21 protein expression. |
| Target gene: | SIRT1//ENOS//COX-2 |
| R-EF-Target gene: | Activation//Upregulation//Upregulation |
| Official symbol(s): | SIRT1//ENOS//COX2 |
| Target gene experiment: | qRT-PCR |
| Target gene description: | RWE increased SIRT1 gene expression (by 14+?10 % at 10 min of exposure, n=8, P<0.05; results not shown).RWE up-regulated eNOS and COX-2 in HUVECs . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: