Aging Overview

External factors

External factors: Imatinib(IM)
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Fibrosarcoma
Experimental category: HL
Tissue type: Tumor tissue
Cell name: Primary tumor cell
PMID: 27608549
Experiment: SA-β-gal activity assay//qRT-PCR//Immunohistochemistry
Description: IM-treated tumors showed a significant up-regulation of the cell-cycle inhibitor p21Cip1 (cyclin-dependent kinase inhibitor (CDKI)1A/CDKN1A) and a marked decrease in cell proliferation, as evidenced by Ki-67 staining.in a subset of IM-treated cases for which material was available, senescence-associated β-galactosidase activity was clearly detectable in the post-IM specimens.Taqman quantitative real-time PCR (Applied Biosystems Division, Foster City, CA) of RNA obtained from macrodissected areas of the post-therapy samples (Pt7 and Pt11) showed a proinflammatory signature characterized by the expression of IL6, TGFB1, PAI1, CXCL1, IL1B, and IL8, which is a cytokine and chemokine profile consistent with the senescence-associated secretory pathway described previously.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.