| External factors: | PTP |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Colorectal cancer |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | SA β-galactosidase-stained HCT116 cells increased by 4.3- and 6.7-fold after treatment with 5 and 10 μM PTP, respectively, for 6 days. The cell cycle analysis revealed that HCT116 cells were arrested at the G1 phase of the cell cycle after 24 h of exposure to 10 μM PTP. |
| Target gene: | P53 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | P53 |
| Target gene experiment: | Western blot |
| Target gene description: | Treatment with 10 M PTP increased the p53 protein level in a time-dependent manner in HCT116 cells expressing wild-type p53. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: