| External factors: | Testosterone |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Immunostaining |
| Description: | DHT-treated SAMP8 showed a reduction of SA-β-gal-stained endothelial cells and increased SIRT1 expression compared to untreated SAMP8. DHT or testosterone treatment inhibited SA-βgal activity and the morphological appearance of senescence . |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | Western blot//qRT-PCR |
| Target gene description: | DHT treatment increased the protein and mRNA expression of SIRT1 in SAMP8 . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: