| External factors: | CGRP |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Telomerase activity assay |
| Description: | AngII was able to accelerate EPCs senescence as shown by the increased percentage of positive SA-β-gal staining cells and the decreased telomerase activity concomitantly with the increase in the mRNA expression of NADPH oxidase gp91phoxsubunit and intracellular ROS production shown by fluorescent dichlorofluorescein.These effects were reversed by exogenous administration of CGRP in a dose-dependent manner. |
| Target gene: | KLOTHO |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | KLOTHO |
| Target gene experiment: | Western blot//PCR |
| Target gene description: | AngII was able to accelerate EPCs senescence as shown by the decrease in the expression of both Klotho mRNA and secreted Klotho protein,The effect was reversed by exogenous administration of CGRP in a dose-dependent manner. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: