| External factors: | Curcumin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Flow cytometry//SA-β-gal activity assay |
| Description: | Cell cycle arrest in the G1 and G2 phase was observed already 24 h after treatment and lasted for several days. The activity of senescence associated-β galacto -sidase increased already on day 3 and after 7 days almost all cells were SA-β-gal positive. |
| Regulatory pathway: | p53-p21//Rb |
| R-EF-Pathway: | Activation//Downregulation |
| Official symbol(s): | TP53-CDKN1A//RB1 |
| Pathway experiment: | Western blot |
| Pathway description: | We observed quite rapid (several hours after curcumin treatment) activation of the p53/p21 signaling pathway and a decrease in Rb. The latter protein almost completely disappeared after 7 days of treatment). |
Annotation: