| External factors: | Cisplatin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Esophageal cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | Cisplatin significantly elevated cellular senescence in EC109 cells in a time-dependent manner. |
| Regulatory pathway: | ERK1/2 |
| R-EF-Pathway: | Activation |
| Pathway experiment: | SA-β-gal activity assay//Western blot//PI staining//Annexin V binding assay |
| Pathway description: | Treatment of cisplatin obviously stimulated the phosphorylation of ERK1/2, p38, and JNK.inhibition of ERK1/2 significantly suppressed cisplatin-induced apoptosis and senescence in EC109 and EC109/CDDP cells . |
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