| External factors: | Radiation |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Breast cancer |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | Cell cycle analysis revealed induction of a G2 arrest in the total population of T47D cells after 5 × 3 Gy, from 14.7% to 21.5%. After fractionated radiation with 5 × 3 Gy, the total population of T47D cells showed a 3.6-fold increase of cells in the G0 phase of the cell cycle, from 3.31% to 11.9% .At 0 Gy, 2% of the total population was X-gal-positive/senescent cells . Fractionated radiation induced a dose dependent increase of X-Gal+/senescent cells in the total population, with a maximal effect at 5 × 3 Gy (25-fold increase, P = 0.09). |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: