| External factors: | Indomethacin |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | Treatment of endothelial cells at P1 with increasing concentrations of the eNOS inhibitor L-NAME (0.1 10mM) significantly increased SA-β-gal activity.The fact that NAC, NADPH oxidase inhibitors (apocynin and VAS-2870), and indomethacin significantly reduced SA-β-gal activity, and also the increased expression of the senescence markers (p53, p21, and p16). |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: