| External factors: | Urolithin A |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | qRT-PCR//Western blot |
| Description: | Collagen mRNA expression was significantly increased in cells treated with 20 μM and 50 μM urolithin A, and mRNA expression of MMP-1 significantly decreased in a urolithin A dose-dependent manner.We found that type I collagen expression in urolithin A-treated cells was upregulated, while MMP-1 expression was significantly downregulated. After a 5-day treatment with urolithin A, the intracellular ROS level was significantly reduced., suggesting that urolithin A attenuated ROS in senescent cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: