| External factors: | EGCG |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | SA-β-gal activity significantly(p＜0.05) enhanced in H2O2treated cells with over 60% cells appearing senescent as compared to control group, which was significantly (p＜0.05) abrogated on treatment with EGCG. |
| Regulatory pathway: | Bcl-2 |
| R-EF-Pathway: | Downregulation |
| Official symbol(s): | BCL2 |
| Pathway experiment: | Western blot |
| Pathway description: | Assessment of underlying molecular mechanism for apparent senolytic effects of EGCG revealed a strong upregulation of Bcl-2 protein expression in senescent cells which was dose dependently and significantly (p＜0.05) abrogated by EGCG treatment. |
Annotation: