Aging Overview

External factors

External factors: Gamma-tocotrienol
Aging type: Prevent
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: Foreskin
Cell name: HDF
PMID: 22358238
Experiment: Flow cytometry//qRT-PCR//SA-β-gal activity assay
Description: γ-Tocotrienol c-Tocotrienol significantly decreased (p,0.05) the percentage of senescent HDFs in the G0/G1phase. In contrast,c-tocotrienol significantly increased (p,0.05) the percentage of senescent HDFs in the G2/M phase.However,c-tocotrienol produced significant downregulations of MMP1 mRNA expression in pre-senescent and senescent HDFs compared to untreated cells (p,0.05).c-Tocotrienol produced significant(p,0.05) upregulations of COL1A1 in young, pre-senescent,and senescent HDFs. c-Tocotrienol also significantly upregulated ELN mRNA in young and senescent HDFs. c-Tocotrienol significantly downregulated IL6, CCND1 and RB1 mRNA expression in senescent HDFs (p,0.05)..The incubation of senescent cells with 70 mM c-tocotrienol did not alter the percentage of SA-β-gal-positive cells.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.