| External factors: | Azelaic acid |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis//qRT-PCR//ELISA |
| Description: | AzA partly counteracted the cell shape change,AzA treatment after PUVA significantly reduced the SA-β-gal staining intensity .Supplementation with AzA significantly decreased MMP-1 protein concentrations and counteracted the PUVA-induced downmodulation of type I pro-collag. |
| Target gene: | PPARγ |
| R-EF-Target gene: | Activation |
| Official symbol(s): | PPARG |
| Target gene experiment: | Luciferase reporter assay |
| Target gene description: | Our results showed a significant induction of the PPAR-γctranscriptional activity after 24 and 48 h of AzA treatment. Interestingly, PUVA exposure decreased luciferase expression at 24 and 48 h, and AzA 2.5 mM partially counteracted this effect. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: