| External factors: | Indoxyl sulfate |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Chronic kidney disease |
| Experiment: | SA-β-gal activity assay |
| Description: | IS significantly increased the percentage of SA β-gal-positive cells, as scored by counting the numbers of blue and total cells, compared to that observed in the control cells at 24 hours. |
| Regulatory pathway: | AhR |
| R-EF-Pathway: | Activation |
| Official symbol(s): | AHR |
| Pathway experiment: | SA-β-gal activity assay//HDAC colorimetric assay//Immunoblotting |
| Pathway description: | Pretreatment with ANF (10 μmol/L) or CH223191 (10 μmol/L)39), AhR inhibitors, for one hour rescued the IS-induced cellular senescence in the HUVECs. |
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