| External factors: | GSE4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Dyskeratosis congenita |
| Experimental category: | L |
| Tissue type: | -- |
| Cell name: | F9-A353V,DC-C,DC-3,XDC1787-C,F26IIB |
| PMID: | 26571381 |
| Experiment: | SA-β-gal activity assay |
| Description: | A fibroblastoid cell line established from a healthy relative of a DC patient (XDC-1787-C) was used as internal control. Expression of GSE4 and GSE24.2 significantly decreased cell senescence. |
| Target gene: | C-MYC//TERT |
| R-EF-Target gene: | Activation//Activation |
| Official symbol(s): | C-MYC//TERT |
| Target gene experiment: | Western blot |
| Target gene description: | GSE4 and GSE4-NLS1 peptides showed similar capacity than GSE24.2 to activate c-myc and TERT promoters in the cell lines analyzed, including the F9-A353V mutant cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: