| External factors: | HCV infection |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | Flow cytometry//qRT-PCR//Western blot// FISH |
| Description: | Remarkably, at day 3 of TCR stimulation,CD57 expression on CD4+CD45RA+na?ve T cells was significantly increased in HCV patients compared with HS .HCV na?ve T cells exhibited higher mRNA levels of CDKN1A (encodes p21cip1), CDKN2A (encodes p16ink4a), and p53, as determined by real-time RT-PCR. However, we observed increases in p53 protein expression and cleaved poly ADP-ribose polymerase 1 (PARP-1) in unstimulated memory CD4 T cells,as well as increases in p21 and γH2AX levels in TCR-stimulated memory CD4 T cells derived from HCV patients. Telomere length was significantly shortened in HCV-derived total CD4 T cells,as well as in na?ve and memory CD4 T cells compared with HS. |
| Target gene: | TRF2 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | TERF2 |
| Target gene experiment: | Western blot |
| Target gene description: | The TRF2 protein level was significantly downregulated in na?ve CD4 T cells isolated from HCV patients. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: