| External factors: | Valsartan |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Atherosclerosis |
| Experiment: | SA-β-gal activity assay//qPCR//Western blot |
| Description: | When HUVECs were treated with TNF-α together with valsartan or simvastatin, miR-155 expression was significantly reduced, accompanied by a parallel upregulation in SIRT1 expression and a decrease in TNF-α-induced HUVEC senescence . |
| Target gene: | MIR-155 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | MIR-155 |
| Target gene experiment: | qPCR//Western blot |
| Target gene description: | When HUVECs were treated with TNF-α together with valsartan or simvastatin, miR-155 expression was significantly reduced, accompanied by a parallel upregulation in SIRT1 expression . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: