Aging Overview

External factors

External factors: Autophagy
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: WI-38
PMID: 31931659
Experiment: SA-β-gal activity assay//Western blot
Description: 3-MA and LY also inhibited CDKN1A and CDKN2A upregulation as well as SA-GLB1/β-gal activity in serum-starved fibroblasts.


Regulatory relationship

Regulatory pathway: MTORC2
R-EF-Pathway: Activation
Official symbol(s): ARMH4
Pathway experiment: SA-β-gal activity assay//Western blot
Pathway description: Serum-starved fibroblasts exposed to R showed lowered CDNK1A and CDKN2A protein levels and decreased SA-GLB1/β-gal activity .RPTOR silencing led, however, to inhibition of SA-GLB1/β-gal activity.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view