| Gene name: | MEF2A |
| Aging type: | Prevent |
| Aging characteristic: | Others |
| Tissue type: | Human umbilical vein |
| Cell name: | HUVEC |
| Gene ID: | 4205 |
| Category: | protein coding |
| Phenotype: | Cardiovascular disease |
| Experimental category: | L |
| PMID: | 31182679 |
| Experiment: | Cell viability assay//SA-β-gal activity assay |
| Description: | The percentage of senescent phenotype cells in MEF2A overexpression group was significantly lower than that in the empty plasmid group and the MEF2A mutant group (pc-gab-MEF2A-MV30).MEF2A overexpression in HUVECs significantly increased cell viability. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Binding to promoter |
| Target gene experiment: | Western blot |
| Target gene description: | The level of p53 was significantly decreased?in the MEF2A-overexpression HUVECs. |
| Regulatory pathway: | PI3K-P-AKT-SIRT1 |
| R-AG-Pathway: | Upregulation |
| Official symbol(s): | PIK3CA-AKT1-SIRT1 |
| Pathway experiment: | qRT-PCR//Western blot |
| Pathway description: | PIK3CA, PIK3CG, and SIRT1 mRNA levels were significantly up-regulated in the MEF2Aoverexpression HUVECs, and the protein levels of PIK3CA, PIK3CG, SIRT1, and p-Akt notably increased . |
Annotation:
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