| Gene name: | LMNA |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | VSMC,HUVEC |
| Gene ID: | 4000 |
| Category: | protein coding |
| Phenotype: | Hutchinson-Gilford progeria syndrome |
| Experimental category: | HL |
| PMID: | 28423660 |
| Experiment: | Cell morphological analysis |
| Description: | Introduction of progerin into VSMCs strongly reduced cell growth and shortened the replicative lifespan,In contrast, introduction of progerin had no effect on the growth and lifespan of HUVECs. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown |
| Target gene description: | We introduced siRNA targeting p53 into progerin-infected VSMCs and found that this siRNA counteracted the anti-proliferative effect of progerin on VSMC growth. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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