| Gene name: | SRSF1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Primary Fibroblast |
| Experiment: | SA-β-gal activity assay//EdU assay//Cell proliferation assay |
| Description: | SRSF1 overexpression resulted in a 5-fold increase in the number of SA-β-gal-stained cells;Prolonged overexpression of SRSF1 resulted in enlarged and flattened cells with an increased number of intracellular vesicles—phenotypes typical of senescence;Within four days of SRSF1 overexpression, cell proliferation was drastically reduced to only 20% of control cells. |
| Target gene: | RPL5//P53 |
| Official symbol(s): | RPL5//P53 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | RT-PCR//Western blot//Knockdown |
| Target gene description: | siRNA-mediated knockdown of RPL5 in BJ cells severely abrogated the effect of SRSF1 overexpression on p53. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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