| Gene name: | TGFB1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U937 |
| Experiment: | SA-β-gal activity assay//qRT-PCR//SAHF |
| Description: | While SAHF and increased p16 expression was observed already after 3 days, SA-β-Gal was not apparent until 6 days of treatment. No signs of increased proliferation was observed during continued culture during a couple of weeks. |
| Target gene: | MAD1//MYC |
| Official symbol(s): | MAD1//MYC |
| R-AG-Target gene: | Upregulation//Downregulation |
| Subcategory: | Acetylation |
| Target gene experiment: | Western blot |
| Target gene description: | To investigate the effects of TGF-β1 on Myc/Max/Mad network protein expression, the respective proteins were immunoprecipitated from 35S-labeled U-937-myc-6 cell extracts . The synthesis of Mad1 increased substantially;meanwhile, the synthesis of c-Myc decreased after TGF-β1 treatment. A slight decrease in v-Myc synthesis was also observed while no major change in the expression of Max occurred. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...