Aging Overview

Aging gene

Gene name: YAP1
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: h-PDLSC
Gene ID: 10413
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 30123063
Experiment: SA-β-gal activity assay
Description: Staining results showed that the OE YAP group had a lower senescence rate than the OE NC group (P<0.01), which indicates that activated YAP postponed the senescence of h-PDLSCs.


Regulatory relationship

Target gene: CDK6//CYCLIN B1//P18//P27
Official symbol(s): CDK6//CYCLIN B1//CDKN2C//P27
R-AG-Target gene: Upregulation//Upregulation//Downregulation//Downregulation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: In Western blotting, cyclin-dependent kinase 6 (CDK6) and cyclin B1 were upregulated, while CDK inhibitors P18 and P27 were downregulated when YAP was overexpressed.

Regulatory pathway: ERK
R-AG-Pathway: Upregulation
Official symbol(s): MAPK1
Pathway experiment: Western blot
Pathway description: The expression of P-Msk1, which can phosphorylate ERK, increased when YAP was overexpressed. At the same time, the protein levels of P-ERK1/2 and its target proteins P-P90RSK and P-Msk1 increased in the OE YAP group.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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