| Gene name: | FOXM1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay |
| Description: | Moreover, significantly higher numbers of Foxm1-/- MEFs displayed SA-β-gal and senescent morphology compared with WT MEFs following exposure to 5 Gy of g-irradiation. |
| Target gene: | NBS1//P-ATM//FHRE |
| Official symbol(s): | NBN//ATM//FHRE |
| R-AG-Target gene: | --// --// -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Luciferase reporter assay |
| Target gene description: | The result showed that overexpression of FOXM1 caused an induction of NBS1 levels and ATM phosphorylation in MCF-7 cells ,further confirming that FOXM1 regulates NBS1 expression and thus MRN complex formation to promote ATM activation and phosphorylation.We observed the (WT) NBS1 promoter activity was augmented by FOXM1 in a dose-dependent manner, whereas the mut NBS1 promoter had lower basal promoter activity and was not inducible by FOXM1. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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